It’s a fundamental fact that explosions are cool and cancer is not. We all know or have known someone that’s suffered from this horrible disease. It takes the lives of millions each year and a cure has evaded us thus far. But that may be changing soon. Scientists have discovered a way of making cancer cells self destruct by none other than microbes living deep in the ocean.
Pyroptosis is an inflammatory form of programmed cell death where signalling-molecules that activate the immune system are released. In research published in The FASEB Journal, researchers isolated EPS3.9 from deep ocean bacteria (Spongiibacter nanhainus CSC3.9) and analyzed it. The compound, primarily consisting of mannose and glucose, stimulates pyroptosis in human leukemia cells. The cells swell, rupture, and release inflammatory signals that trigger the immune system to fight back.
“Our work not only provides a theoretical basis for developing more carbohydrate-based drugs but also highlights the importance of exploring marine microbial resources,” said Dr Chaomin Sun of the Chinese Academy of Sciences.
Although this research is in the very early stages, it’s exciting news nonetheless. Not only does this give researches new avenues to approach the fight against cancer, but it also highlights the importance of protecting our oceans. As a mostly unexplored area, it could be an immense source of powerful, natural compounds.
When looking at your aquarium today, just think about how many possible cures are brewing in there.
